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[摘要]
目的 为确定湿疹喷雾剂的最佳提取工艺条件。方法 建立了丹皮酚、黄芩苷的定量方法并用于评价工艺,采用正交实验设计优选该制剂的最佳提取方案。结果 用 80 %乙醇回流提取两次 ;加醇量分别为药材量的 10,8倍 ;回流时间分别为 1.5,1.0 h;回流水浴温度控制在 (90± 2)℃左右。结论 按此条件操作,提取效率最高,提取工艺最为合理。
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[Abstract]
Object To optimize the process for the extraction of the original recipe used in the treatment of eczema to give a new ECZEMA SPRAY dosage form Methods The extraction process was studied by orthogonal experimental design as guided by determining the content of paeonol and baicalin in the extract Results The optimal extraction process was to reflux the original recipe with 80% ethanol twice at a bath temperature of about 90 ℃ for 1 5 and 1 0 h respectively The amount of ethanol used for each extraction was 10 and 8 times of the original recipe respectively Conclusion The above extraction process gave the most rational and satisfactory results
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