[关键词]
[摘要]
目的 研究皂角皂苷元的化学结构。方法 通过提取、完全水解、层析等方法 ,从皂角中获得 2种皂苷元,制备系列衍生物并进行红外、核磁共振、质谱和晶体衍射等分析。结果 2种皂角皂苷元分别为 3-羟基 - 12 -齐墩果烯 - 2 8酸和 3,16 -二羟基 - 12 -齐墩果烯 - 2 8-酸。结论 首次确定了 2种皂角皂苷元的化学结构和晶体结构
[Key word]
[Abstract]
Object To study on the structure of sapogenins from pod of Gleditsia sinensis Lam. Methods Pod of G. sinensis was extracted with solvents and th e constituents in the extraction isolated, after hydrolised completely, with t he aid of flash chromatography to obtain 2 gledgenins. Results The structures of the 2 gledgenins were proved to be 3-hydroxy-12-oleanen- 28-oic acid and 3, 16-dihydroxy-12-oleanen-28 oic acid respectively as sho wn by IR, NMR, MS and crystallographic data. The structures were further veri fied by acylation, methylation and followed by reaction with 3, 5-dinitro-be nzoyl chloride. Conclusion New crystalline derivatives were ob tained to provide further evidence of their structures.
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[基金项目]
山东大学晶体重点实验室资助项目;河南省自然科学基金资助项目