目的考察四物汤中白芍与其它各单味药排列组合构成的8种样本药物中苯甲酸煎出量的变化。方法RP-HPLC法进行测定。结果白芍单味药苯甲酸煎出量为2.74mg/g;加其它药味合煎后,苯甲酸煎出量为0.41～1.11mg/g。结论白芍单煎,苯甲酸煎出量较高;而与四物汤中其它药味合煎后,可显著降低苯甲酸的煎出量

Object To determine the change of benzoic acid conte nts in decoctions prepared from various combinations of the recipe named SIWUTANG by RP-HPLC to provide a reference for the control of the acid level. Methods 8 decoctions of P. lactiflora either a l one or in combination with one or more of the other 3 components, according to p ermutation and combination, were prepared and their benzoic acid contents determ i ned by RP-HPLC. Results The content of benzoic acid in the de co ction of Radix Paeonie Alba alone was found to be 2.74 mg/g, wh il e that of the other 7 combinations varied from 0.41～1.11 mg/g. Conclusion The content of benzoic acid in SIWUTANG could be low ered significantly by the presence of Radix Angelica Sinensis, Radix Reh manniae, and Rhizoma Chuanxiong.

国家自然科学基金资助项目，项目编号39670867