[关键词]
[摘要]
从日本七叶树AesculusturbinataBl.种子的90%乙醇提取物中分得3个二萜皂化合物,经光谱学分析鉴定了它们的结构分别为:七叶树皂苷IVc:22α-O-巴豆酰基-28-O-乙酰基原七叶树皂苷配基-3β-O-[β-D-吡喃葡萄糖基(1→2)][β-D-吡喃葡萄糖基(1→4)]-β-D-吡喃葡萄糖醛酸()、异七叶树皂苷Ia:21β-O-巴豆酰基-28-O-乙酰基原七叶树皂苷配基-3β-O-[β-D-吡喃葡萄糖基(1→2)][β-D-吡喃葡萄糖基(1→4)]-β-D-吡喃葡萄糖醛酸()和异七叶树皂苷Ib:21β-O-当归酰基-28-O-乙酰基原七叶树皂苷配基-3β-O-[β-D-吡喃葡萄糖基(1→2)][β-D-吡喃葡萄糖基(1→4)]-β-D-吡喃葡萄糖醛酸(),均为首次从日本七叶树种子中分得。七叶树皂苷Ia、Ib、IVc和异七叶树皂苷Ia、Ib在100μmol/L浓度的体外试验中对HIV-1蛋白酶活性具有一定的抑制作用
[Key word]
[Abstract]
Three triterpenoid saponins were isolated from 90% ethanolic extract of the seeds of Aesculus turbinata Bl Their structures were identified on the basis of spectral data as escin IVc:22α O tigloyl 28 O acetylprotoaescigenin 3β O [β D glucopyranosyl(1→2)][β D glucopyranosyl(1→4)] β D glucopyranosiduronic acid (Ⅰ), isoescin Ia:21β O tigloyl 28 O acetylprotoaescigenin 3β O [β D glucopyranosyl(1→2)][β D glucopyranosyl(1→4)] β D glucopyranosiduronic acid (Ⅳ), and isoescin Ib:21β O angeloyl 28 O acetylprotoaescigenin 3β O [β D glucopyranosyl(1→2)][β D glucopyranosyl(1→4)] β D glucopyranosiduronic acid (Ⅴ) Escin IVc and isoescins Ia, Ib were obtained for the first time from this plant Escins Ia, Ib, IVc and isoescins Ia, Ib had inhibitory effect against recombinant HIV 1 protease at concentration of 100 μmol/L in vitro
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[基金项目]
国家自然科学基金资助项目!No 2 9972 0 0 4