观察通脉活血灵胶囊对实验性高脂血症家兔血脂调节变化和动脉粥样硬化形成的影响。实验结果表明,高脂饲料喂养家兔可导致高脂血症,并可诱发动脉粥样硬化(AS)。通脉活血灵胶囊 2.4,1.2 g/kg组均可明显降低血清总胆固醇、血清甘油三酯、血清低密度脂蛋白,可升高血清高密度脂蛋白 ;并明显抑制AS形成和发展,且有明显的量效关系。

To study the effect of Tongmaihuoxueling Capsule (T MHXL) on blood lipid and atherosclerosis. Hyperlipidemic rabbit models were pre p ared by feeding high lipid diet for 12 weeks. High, medium and low doses of TMH X L were fed thereafter. Their blood lipid levels were messured at the 12th week . The aorta was isolated and stained with sudan Ⅲ and hematoxylin-eosin to exami ne the gross and microscopic evidences of atherosclerosis. TMHXL could decrease the serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein c holesterol (LDL-C) content, but elevate the high density lipoprotein cholestero l (HDL-C) and prevent the formation of atherosclerosis. TMHXL is effective for the prevention of hyperlipidemia and the development of atherosclerosis.