[关键词]
[摘要]
为研究小分子多肽类物质心肌肽素抗心肌缺血-再灌流损伤作用, 在大鼠离体Langendoff’s心脏缺血-再灌流损伤模型上, 观察心肌肽素对室颤(VF)发生率及心肌生化指标的影响。结果发现:心肌肽素能明显降低离体缺血-再灌流损伤心脏VF的发生率;剂量依赖性地降低心肌乳酸脱氢酶(LDH)活性和丙二醛(MDA)含量;提高心肌肌酸磷酸激酶(CPK)活性。提示心肌肽素对缺血-再灌流损伤心肌有保护作用, 这可能与其抗脂质过氧化和影响心肌酶的活性有关。
[Key word]
[Abstract]
Effects of the low molecular weight polypeptide cardiomyopeptidin (CMP) on ischemia reperfusion injury (IRI) inflicted on myocardium of the Langendorff model of isolated rat heart were studied. The results showed that CMP could obviously decrease the incidence of ventricular fibrillation in heart damaged by IRI; reduce the activity of LDH and MDA content and increase the activity of CPK in anterior wall of ventricular myocardium in a dose dependent manner. The results indicated that CMP had a protective effect on IRI infliction of the myocardium which be related to its inhibitory effect on lipid peroxidation and influencing the activities of myocardial enzymes.
[中图分类号]
[基金项目]
“九·五”国家重点科技攻关项目(No.96-902-01-04)