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[摘要]
采用测定大鼠胆汁分泌量的实验方法,观察栀子提取物京尼平苷和西红花苷十二指肠给药后的利胆作用。结果显示西红花苷50和 100 mg/kg剂量均不增加大鼠的胆汁流量,而京尼平苷50和 100 mg/kg剂量均可显着增加大鼠胆汁流量,降低胆汁内胆固醇。
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[Abstract]
Effects of geniposide and crocins,the two extracts from Gardenia jasminoides Ellis,on the biliary secretion in rat were investigated. It was observed that,at the doses of 50 mg/kg and 100 mg/kg.geniposide could significantly increase the biliary secretion after intraduodenal administration. while crocins showed no effect. On the other hand,geniposide can markedly decrease the content of cholesterol and elevate HCO3concentration in bile, but without effect on the level of bilirubin, bile acid and Ca2+. The results show that geniposide is the main choleretic principle in Gardenia jasminoides Ellis.
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