[关键词]
[摘要]
采用左心室及血管插管法,研究了洛土辛(Lot)对大鼠及狗血流动力学的影响。 Lot 2.5,5,10 mg/kg,iv可剂量依赖性地增加麻醉大鼠的左心室压(LVP)、左室压力变化最大速率(±dp/dtmax)、动脉收缩压(SAP),降低左室舒张末期压(LVEDP),但对心率(HR)和动脉舒张压(DAP)却无明显的影响。麻醉大鼠 Lot 5 mg/kg、麻醉狗 Lot 3 mg/kg,iv可获相似结果,其对狗血流动力学影响的起效时间较快且作用持续较长。在毁脊髓大鼠,Lot 5 mg/kg,iv不仅显着地增加 LVP,±ap/dtmax,SAP,明显增加DAP和HR.提示Lot对血流动力学影响的特性与PDE Ⅲ抑制剂相似.
[Key word]
[Abstract]
Lotusine (Lot),a pure alkaloid extracted from the green seed embryo of Nelumbo nuciferaUaertn,has been demonstrated to possess the properties of phosphodiesterase 3 inhibitors in isolated my-ocardium and blood vessels. In this paper,the effects of Lot on haemodynamics were studied in rat and ca-nine,Lot 2.5,5,10 mg/kg,iv could obviously increase left ventricular pressure (LVP),systolic or diastolic maximum rate of pressure change(士dp/dt ),left ventricular end diastolic pressure (LVEDP) and systolic artery blood pressure (SAP) in dose-dependent manners. But there is no significant influence on diastolic artery blood pressure (DAP) and heart rate(HR).In anesthetized rat, with Lot 5 mg/kg,iv and anes-thetized canine with Lot 3 mg/kg,iv,results similar to the above could be obtained. Moreover, it was found that the effect of Lot on anesthetized canine appeared earlier and was more persistent than that on anes-thetized rat. In pithed rat,Lot 5 mg/kg,iv enhanced not only LVP,士dp/dt,SAP, but also DAP and HR.The results suggested that the properties of the effect of Lot on haemodynamics are similar to that of phos-phodiesterase Q inhibitors.
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[基金项目]
武汉市科委自然科学基金