观察了川乌与白芍及川乌与防己两组药对配伍前后对小鼠热板疼痛和家兔K⁺皮下致痛、齿髓致痛3种疼痛实验模型的影响。发现两组药物在配伍后均可使镇痛作用明显增强，并且镇痛持续时间显着延长，其中多数测定结果均优于消炎痛和各药单独使用，有统计学意义。

According to ancient TCM concept, a combination of "cold" and "hot"-natured drugs could be used to treat arthralgia syndrome. Two famous classical drug combinations of this type, monkshood root combined with peony root and monkshood root combined with tetrandra root, were studied on modern hotplate, scinjection of K⁺solutions and toothache pharmacologic tests. Their analgesic effects were found to be very significant. A review on the classical treatise [A Collection of Chinese Famous Prescriptions]showed that 109 of the 173 prescriptions for the treatment of arthralgia syndrome contained both "hot" and "cold" natured drugs,proving that such concept was rather infallible.

国家自然科学基金(39670868)