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[摘要]
采用伤寒-副伤寒菌苗致热家兔法研究赛葵的解热作用,热板法和扭体法研究赛葵的镇痛作用,二甲苯致炎鼠耳肿胀法和腹腔毛细血管通透性法研究赛葵的抗炎作用.结果表明:赛葵全草 10、20 mg/kg ig给药能降低发热家兔的体温,延长小鼠的痛反应时间,减少扭体鼠数和扭体次数,20 mg/kg抑制鼠耳的肿胀及抑制小鼠腹腔毛细血管通透性;赛葵根 10 mg/kg ig给药能降低发热家兔的体温,抑制鼠耳的肿胀,降低小鼠腹腔毛细血管通透性.提示赛葵具有解热镇痛抗炎作用。
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[Abstract]
Antipyretic, analgesic and anti-inflammatory effects of Malvastrum coromandelianum (L.)Garcke were tested by fever caused by typhoid-paratyphoid vaccine in rabbits; hot-plate, writhing, ear edema, and abdominal capillary permeability of mice. Results of the study showed that both aqueous extract of whole plant or root of M. coromandelianum (L.) Gurcke at doses of 10, 20 mg/kg, po equivalent to the crude plant could lower rabbit fever (P<0.05, P<0.01), decrease mice writhing (P<0.01), inhibit ear edema (P<0.05), and decrease the permeability of the blood capillary in abdominal cavity of mice (P<0.01). These results suggested that M. coromandelianum (L.) Gurcke has antipyretic, analgesic and anti-inflammatory effects.
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