[关键词]
[摘要]
采用V-C扩散池及小鼠皮肤建立的透皮模型和紫外可见分光光度法,考察了不同pH值及其条件下氮酮(Azone)对大黄提取物中大黄酚透皮吸收的影响.结果表明:大黄酚在酸性介质中的透皮效果最佳,且Azone对其透皮吸收有显着增强作用.
[Key word]
[Abstract]
Effects of pH and azone on the transdermal absorption of chrysophanic acid by mouse skin were studied in vitro by Valian-Chien horizontal di-ffusion cell and UV spectrometry.Result of the study showed that maximum absorption was attained at pH4 and that azone is an excellent trans-dermal penetrant to enhance absorption.
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[基金项目]
国家自然科学基金, 39360084;江西省自然科学基金