大鼠腹主动脉部分狭窄5周后,形成实验性心肌肥厚模型,心肌和左心室重量明显增加,心肌过氧化脂质(LPO)含量显着增加,SOD活性下降,心肌和主动脉Ca²⁺ 含量明显增加.给槲皮素75、150 mg/kg后均能明显降低心肌和左心室重量,降低心肌LPO含量,增加SOD活性,降低心肌和主动脉Ca²⁺的含量,提示槲皮素抗心肌肥厚作用与清除氧自由基和钙拮抗有关.

Cardiac hypertrophy models of rat were prepared by coarctation of abdominal aorta for 5 weeks,which resulted in a significant increase of myocardium and left ventricular weights.Lipid peroxidation(LPO) products and calcium contents of myocardium and aorta were also increased with decrease of superoxide dismutase(SOD) activity.After treatment with quercetin 75 mg/kg and 150 mg/kg for 5 weeks,the myocardium and left ventricular weights decreased significantly LPO products and calcium content of myocardium and aorta were lowered with increase of SOD activity These results suggested that the effects of quercetin for the prevention of cardiac hypertrophy may be related to its ability to scavenge oxygen free radicals and antagonize calciumions.