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[摘要]
采用硅胶柱预处理-HPLC对自制组曲H-18及市售组曲中的洛伐他汀进行了定量分析, 线性范围 0.65~5.72μg/mL,r=0.9999,加样回收率为96.4%,RSD=3.68%。结果表明,各地产 红由商品药材中有 7种洛伐他汀未测出或只有痕量,5种含量甚微(0.088~0.551μg/g生药),而 自制组曲H-18的洛伐他汀含量最高,达5μg/g生药。
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[Abstract]
Hongqu,a well known TCM prepared by fermenting rice with Monascus purpureus Went (Mona scaceae),used for the promotion of blood circulation and to resolve blood stasis,was speculated to contain some "statins". Pretreatment-HPLC is applied to determine lovastatin in Hongqu H-18 made in our own laboratory and some other commercially available Hongqu samples. The standard curve is linear in the concentration range of 0. 65-57. 2μg/mL,the correlation coefficient is 0. 9999. The average recovery rate is 96.4%and relative standard deviation 3. 68%(n=5). The results showed that Hongqu from different commercial sources contain no or only a small amount of lovastatin (0. 088~0. 551μg/g), but amounted to almost 5μg/gin Hongqu H-18.
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