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[摘要]
大鼠哮喘连续激发后肺组织胞膜β-AR和脑浆cAMP水平逐日下降, 在第7目明显低于正常对照组(P<0.01);激发第7日, 龟芪散明显上调β-AR密度(P<0.05)并使cAMP水平明显上升(P<0.05)。提示龟芪散治疗哮喘可能与其上调β-AR, 提高cAMP水平作用有关, 联合用药可提高糖皮质激素的疗效。
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[Abstract]
Guiqisan (GQS),a recipe with kidney-nourishing and spleen-invigorating effects, has been shown to prevent asthmatic attacks effectively in clinics. GQS was administered to rat a week before the experiment and consecutively during the experiment(2. 4 g/d,rat) daily while the rat was consecutively challenged with asthmatic attacks. "The 3-adrenergic receptor ((3-AR) density and CAMP level of lung tissues in the rat were determined by radio ligand-binding assay and radioimmunity assay at 1st, 3rd and thday. Results showed that the 3-AR density and CAMP level of asthmatic control group gradually decreased to significant low levels on the 7th day (P<0. U1),while that of the GQS pretreated group showed a statistically significant eievarion on the 7th day (P<0.05)."The above results indicated that GQS can elevate the decreased,3-AR density and CAMP level of lung mssues in asthmatic rat and seemed to enhance the j}-AR up-reg-ulation effect of beclomethasone dipropionate (BDP) when GQS and BDP were administered simultaneously.
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