以整体麻醉SD大鼠心脏冠状动脉左前降支结扎/松开作为缺血/再灌注动物模型, 研究丹参注射液(SM)在加强缺血须处理(IP)的心肌保护中的作用。结果显示, IP能减轻复灌性心律失常的严重程度, 缩小心肌梗死范围；SM能缩小心肌梗死范围；SM联合IP与单纯IP比较, 心肌梗死范围进一步缩小；SM联合IP与单纯SM比较, 心律失常严重程度减弱且心肌梗死面积进一步减小。结果表明, SM能加强IP的心肌保护作用, 特别是加强IP的抗心肌梗死作用。

The role of injectio Salvia miltiorrhiza (SM) on enhancing the cardioprotective effect. of is-chemic preconditioning (IP) in anaesthetized rat was investigated. Results showed that IP reduced the severity of reperfusion-induced arrhythmia and limited the infarct size. SM limited the infarct size;SM-f-IP significant1y reduced the infarct size as compared with IP alone;and significantly decreased both the infarct size and the severity of reperfusion-induced arrhythmia as compared with SM alone. These results suggested that SM can enhance the cardioprotective effects of IP.

卫生部、浙江省自然科学基金;浙江省中医局资助