用放射配基结合分析法测定心肌β受体，观察老年大鼠心肌β受体的变化及中药人参、黄芪、枸杞子的影响。结果表明，心肌β受体最大结合容量（Bmax）在3、8、15月龄组间无显著差异，26月龄组显著降低。人参、黄芪、枸杞子对15月龄大鼠心肌β受体Bmax无明显影响，人参和枸杞子可显著提高26月龄大鼠心肌β受体Bmax，黄芪虽可使26月龄大鼠心肌β受体Bmax有所升高，但无显著性差异。表明衰老大鼠心肌β受体密度降低，中药可使之显著升高。提示对心肌β受体数目的调节是这些中药发挥抗衰老作用的分子基础之一。

The change of heart β-adrenoceptor of rats during natural aging process and the regulatory action of Panax ginseng,Astragalus membranaceus,Lycium chinense were observed. Radioligand binding assay revealed that the maximum binding capacity (Bmax) did not change significantly in 3-, 8-, or 15-month-old rats,while in 26-month-old rats,it was significantly lowered. P. ginseng and A. membranaceus,L. chinense did not obviously effect the Bmax of heart β-adrenoceptor in 15-month-old rats, while in 26-month-old rats,P. ginseng and L. chinense could upregulate the Bmax significantly. A. membranaceus showed an upregulatory action to some extent,but without statistical significance. Conclusion: These three Chinese herbs have an up regulatory effect on the heart β-adrenoceptor densities of aged rats.

国家自然科学基金