利用计算机自动控制、图像分析处理和多媒体视频等多种技术，将小鼠在圆形水迷宫的学习记忆行为表现转换为活动图像并显示其实时运动轨迹路线，利用计算机对获得的信息资源进行综合分析、优化组合后，建立了由运动距离、速度、寻找平台时间、运动轨迹组成的评价指标。正常动物及慢性ig酒精实验结果证明上述指标更为规范客观、科学准确，更符合小鼠在圆形水迷宫内的学习记忆行为表现。从而为益智中草药研究提供了一种自动化程度高、获取信息量大、符合国际标准的圆形水迷宫计算机自动控制和图像分析处理系统及相应的指标评价体系。

By making use of the dominant position in pharmacy, electronic,engineering and computer sciences,and by converting learning and memory behavior of mice in circle Water-Maze into locus patterns of rea1 time with the techniques of photography,multimedia and computer-based auto-controlling,a computeraided auto-controlling and image-analysing processing system for studying animal spatial discrimination in circle Water-Maze have been set up.Experimental results with normal mice and dementia animals induced by 20-30% alcohol showed that the system can provide more information including time to find the platform of ecircle Maze,the scores of their performance,their speed of swimming in the Maze and the number of mice to reach the destination,and the scattering atlas of mouse locus moving in the circle Water-Maze of mouse.The system have been proved to be more systematic,scientific and reasonable for the judgment of spatial discrination of the tested animal in circle Water-Maze,and can be regarded as an advanced tool for pharmacological study of nootropic Chinese Medicinal herbs with high degree of automation.

国家科委生命中心博士新医药创新项目