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[摘要]
麻醉开胸犬iv1.25、2.5μg/kg狭叶黎芦碱甲(V3)后,平均动脉压、心率、左室收缩压、右室内压最大上升速率及心脏做功均明显降低,5min内最强,并且作用随剂量的增加而加强;对心输出量无明显影响;冠脉血流和脑血流亦无显著改变。小鼠iv的LD50为1.1mg/kg。
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[Abstract]
Effects of stenophylline A(V3),1. 25 and 2. 5 ug/kg,iv on hemodynamics were studied in 6 anesthetized dogs. V3dose-dependently decreased mean arterial pressure,heart rate,left ventricular systolic pressure,dp/dt max with little influence on cardiac output ,coronary and cerebral blood flow. The action appared immediately after administration,reached the highest in 5 min,and lasted 20-40min. There was no tachyphylaxis. The LD50(iv) was about 1. 1 mg/kg.
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