[关键词]
[摘要]
花椒毒酚(xanthotoxol,XT)是从蛇床子中提取出的一种呋喃香豆素。XT对二甲苯所致小鼠耳壳肿胀、醋酸引起的小鼠腹腔毛细血管通透性增高、大鼠角叉菜胶性足跖肿胀均有明显的抑制作用,对小鼠棉球肉牙肿增生也有明显的抑制作用。结果表明XT对急性和慢性炎症模型均有抗炎作用。此外,XT明显降低大鼠角叉菜胶性足跖炎症组织内PGE含量。
[Key word]
[Abstract]
Xanthotoxol (XT) is a furan-coumarin isolated from the fruit of cnidium monnieri (L.)Cusson. XT suppressed the swelling of mouse ability induced by HAc in mice tion of granuloma induced by and edema imlpanting ear induced by xylene,the increase of peritoneal capillary perme of rat hind paw induced by carrageenan. XT inhibited the proliferacotton pellets in mice. These results indicated that XT diminished acute and chronic inflammation in animal models. Furthermore,XT decreased the contents of prostaglandin E in inflammatory tissue of rat hind paw induced by carrageenan.
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[基金项目]
卫生部拨款资助