通过强迫游泳模型初步研究了柴胡皂甙和氟西汀的抗抑郁作用, 发现4～16mg／kg柴胡皂甙不能缩短小鼠和大鼠强迫游泳不动时间, 氟西汀20和40mg／kg也不能缩短小鼠和大鼠强迫游泳不动时间, 80mg／kg方有作用, 而亚活性浓度的氟西汀(20mg／kg)加上柴胡皂甙能缩短小鼠强迫游泳不动时间, 说明柴胡皂甙单用难以起到抗抑郁作用, 与氟西汀合用能加强其抗抑郁作用。

Antidepressant effect of saikosaponin and fluxotin were studied. In mice and rats forced swimming test (FST),immobility times were not reduced by =9~l6mg/kg saikoaaponin but were only reduced by 80mg/kg fluxotin.When saikosaponin was in combination with aubactive dose of fluxotin (20mg/kg),immobility times were significantly reduced.The results suggested that saikosaponin has a synergistic effect with fluxotin as antidepressant.