研究绞股蓝总皂甙（GPS）对外源性氧自由基所致家兔脑基底动脑损伤的保护作用，外源性氧自由基由电解克氏液产生，电解后，脑基底动脉灌注压及血管壁丙二醛（MDA）含量明显升高，脑基底动脉内皮舒张作用，亚硝酸盐及超氧化物歧化酶（SOD）活性明显降低，GPS25、50、100μg／mL可浓度依赖性地抑制氧自由基诱发脑血管收缩作用，此外GPS100μg／mL还具有明显抑制血管壁MDA生成，保护SOD活性的作用。

Protective effect of gypenoside (GPS)against damges induced by exogenous oxygen free redicals(OFR)on rabbits basilar artery was studied. Exogenous OFR were generated by electrolysis of Krebs solution. The per-fusion pressure and malonyldialdehyde(MDA)content in basilar artery were increased，release of Endotheli-um-ferived relaxing factor (EDRF)，nitrite content and SOD activity in basilar artery decreased afer OFR damage. GPS 25 , 50,100 leg/mI, pretreatment exhibited a concentration dependent decrease in constriction re-sponse of basilar artery. Results also showed that GPS 100 lcg/mL reversed the rise of MDA and the reduc-tion of SOD activity,nitrite and EDRF release.

湖南省自然科学基金