[关键词]
[摘要]
采用胆固醇饲喂日本大耳白家兔3个月,以造成主动脉粥样硬化病变模型,在建立动物模型的同时,给予疏肝活血复方中药,待实验结束时,取血测试,观察该中药对血钙浓度,血浆环核苷酸浓度的影响,结果显示,该中药可明显降低Ca2+浓度,升高环磷酸腺苷(cAMP)/环磷酸鸟苷(cGMP)比值.提示疏肝活血方对动脉粥样硬化(As)的防治起到积极作用.
[Key word]
[Abstract]
Atherosclerotic model of rabbit was established by feeding cholesterol for three months.At the sametime,part of the animals were treated with prescription to soothe,the liver and promote blood circulation.Blood samples were taken at the end of the experiment to examine the effect on blood calcium concentrationand cyclic nucleoside-phosphate content.Results showed that the prescription could significantly reduce bloodcalcium,and raise cAMP/cGMP ratio which suggested that the prescription could restrain the formation ofatherosclerosis effectively,and also delay its development.
[中图分类号]
[基金项目]
天津市自然科学基金