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[摘要]
三七三醇皂甙(PTS)在体外(1~4mg/ml)和体内十二指肠给药(75~300mg/kg)都明显抑制由ADP、胶原、花生四烯酸(AA)诱导的大鼠及家兔血小板聚集,同时亦抑制胶原诱导大鼠血小板TXA2释放,而对大鼠胸主动脉壁PGI2生成无明显影响。PTS(50~200mg/kg)明显抑制大鼠实验性血栓形成,剂量与效应相关。提示:PTS抗血栓作用与其抑制血小板聚集和TXA2释放有关。
[Key word]
[Abstract]
Panaxatriol saponin(PTS), isolated from Panaz pseudo-ginseng var.notoginseng, l~4mg/ml inhibited rabbit platelet aggregation induced by ADP,collagen and arachidonic acid respectively in vitro. In rat,PTS75~300mg/kg intraduodenally inhibited dose-dependently platelet aggregation induced by these inducers,andalso inhibited platelet thrombonane AZ release induced by collagen,but didnot affect the formation of aortic wall PGIZ,PTS50~200mg/kg significantly inhibited experimentALThrombosis in rats. These results showed that the anti-thrombosis action of PTS may be due to its inhibitory action on platelet aggregation and TXAZ release.
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