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[摘要]
观察了槐胺碱(SA)对正常小鼠免疫功能的影响。结果表明:SA15、20mg/kg减低胸腺重量,降低E花环形成率,抑制T淋巴细胞转化,但对脾脏重量无明显影响,也不影响脾脏溶血空斑形成。SA25mg/kg则显著降低胸腺和脾脏重量,降低E花环形成率,抑制T淋巴细胞转化。而各剂量SA均不影响腹腔巨噬细胞吞噬功能。
[Key word]
[Abstract]
The effects of sophoramine (SA) on immune system in normal mice were studied. SA 15. 20mg/kg reduced the weight of thymus,decreased the rate of E rosette,and also suppressed T lymphocyte transformation. The weight and the hemolytic plaque of spleen were not influenced by SA at 15. 20mg/kg. At the dose of 25mg/kg,SA reduced the weight of thymus and spleen,decreased the rate of E rosette and suppressed the T lymphocyte transformation. All of the doses of SA didn' t affect the phagocytotic function of peritoneal macrophage.
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