雷公藤醋酸乙酯提取物对佐剂关节炎大鼠不同病变时期各连续灌胃给药7d,可使致炎2周和4周大鼠的全血高切粘度,全血低切粘度,血浆粘度,全血还原粘度,血球压积,纤维变白原含量均明显降低.对血沉,血沉方程K值无显著影响.说明雷公藤是通过影响红细胞和血浆成分两方面来发挥降低血液粘度作用的.

Ethyl acetate eztraot of Tripterygiurn wlford i(20ng/kg,40ng/kg),given to adju vent arthritis rats(ig)for 7 consecutive days,markedly decreased both high and low shear whole blood viscosity,plasma viscosity.whole blood reduction viscmsity,hematocrit and fibrinogen content,but without effect on blood sedimentation and K value in blood sedimeata,tion equation.T hese results indicated that the decreasing effect of T, wilfordii on blood viscosity may be related to ins inflaenee on red blood cells and plasna composition.