[关键词]
[摘要]
传统治喘名方五虎汤在体外和活体内均具有抑制呼吸道合胞病毒作用.在Hep-2细胞单层上,五虎汤抑制50%以上病毒空斑的浓度为1:80,在此一浓度,病毒繁殖量下降10-2.4TCID50,病毒核酸合成下降率约55%.方中麻黄具有抗RSV活性,其抑制50%以上病毒空斑浓度为1.6mg/ml.在动物体内,本方通过雪化吸入或口服,能降低小鼠肺组织内RSV滴度,促使小鼠肺组织RSV提前消失,并能促进小鼠肺组织炎症吸收.
[Key word]
[Abstract]
Wuhutang,a well known traditional Chinese, herbal decoctjort for thp treattq}nt of asthma was foqnd to have an antiviral effect on respiratory syncytial virus(R SV)both in vitro and in vivo.A 50%reduction of plaque, formation was observed on Hep-2 cell monol-aver at a concentration of 1:80, At such concentration, the value of 1g TC ID50 of viral yield was 2.1,and 55% RNA synthesis of RSV was inhibited.It was found that among the five medicinal herbs in prescription Ephedra sinica Stapf is responsible for the antiviral.
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[基金项目]
国家自然科学基金