苦丁茶冬青叶的提取物静注可使麻醉犬血压显著下降；灌胃给药可使清醒2K₁C型高血压大鼠和SHR的血压显著下降；显著减少正常和肥胖大鼠的腹部皮下脂肪组织指数，提示其具有降压和消肥作用。急性毒性试验，昆明种小鼠灌胃18．8g／kg10d内未出现死亡，生长良好；腹腔注射LD₅₀为3．6±0．6g／kg（P＝0．95）。

Intravenous injection of an extract of Ilex kudingcha leaves remarkably lowered the blood pressure of anesthetized dogs, Blood pressure were also lowered when given to unilateral kidney ligated conscious rats or SHR by gistric giviga. Whea given orally to adult or obesic rats, their abdominal subcutaneous fatty tissue deceased markedly, These results auggested that the extinct posses antihypertensive and weight reducing activities，LD₅₀ of the extract is mice was 3.6±0,6g/kg by iP route.