用清醒大鼠冠状动脉前降支阻塞造成急性心肌梗死及再灌注损伤模型观察槐胺碱（SA）对梗塞范围及再灌注心律失常的作用。SA13．3和15mg／kg显著缩小心肌梗塞范围，降低血清LDH含量，减轻清醒大鼠缺血早期心律失常。胺碘酮7．5mg／kg有类似作用。SA13．3和15mg／kg也可显著缩短再灌注心律失常持续时间，降低室颤的发生率。

The effects of sophora mine(SA)on myocardial infarction size and ischemia-induced and reperfusiou-induced arrhythmia were studied in conscious rats. It was found that pretreatment with SA 13.3 and 15 mg/kg tv reduced significantly infarct size and cardiac LDH release at 6 h afte left descending coronsry artery ligati}n as com pared with the control. S A 10.6, 13.3 sad 15 mg/kg iv decreased m arkedly the early ische mic arrhyth min in conscious rats. A miodarone }.5mg. kg-1，had the same effects on the prevention of ischemic arrhythmia. In reperfusion experiment, it decreased the i-}cide^ce of ventric aar fibrillation and significantly shortened the duration of arrhythmias. These results suggest that SA hgs protective effects on myocardial ischemia and reperfusion injury.