[关键词]
[摘要]
从夏枯草中提取夏枯草总皂甙(PVS),PVS40mg/kg腹腔注射对麻醉大鼠1gPVC,1g(VT+VF)及心律失常得分,较对照组有显著减少。20mg/kg腹腔注射对麻醉大鼠冠脉结扎后4h,心肌梗死范围较对照组有缩小,2.5mg/kg静脉注射开始对麻醉大鼠的舒张压和收缩压有显著下降。
[Key word]
[Abstract]
Effects of total saponins from Prunella vulgaris(PVS)on acute myocardial infarction and hypertension of anesthetized rats were assessed, Pretreatment with PVS at a dose of 40mg/kg ip lowered Lg PVC, Lg(VT+VF)and ischemic arrhythmic scores, at a dose of 20mg/kg ip, resulted in a significant reduction of infarct size as compared with the controls, 2,5mg/kg iv showed an hypotensive action to both systolic and diastolic blood pressure
[中图分类号]
[基金项目]
现在北京军区总医院药械科(100700)