采用四氧嘧啶制备糖尿病大、小鼠模型, 观察血糖平对其血糖的影响。血糖平2.5g/kg, 灌胃, qd, 连续7d, 对糖尿病小鼠血糖有明显的降低作用, 而对正常小鼠血糖无降低作用。血糖平1.5g/kg或0.75g/kg灌胃, qd, 7d或14d, 对糖尿病大鼠血糖都有明显降低作用, 并有剂量、时间依赖性。 14d时对糖尿病大鼠血脂和血清脂质过氧化物也有明显降低作用。 提示血糖平的抗氧化活性与其降糖作用可能有一定关系。

Effects of "Xuetangping", a herbal prescription composed of Radix Astragali, Radix Trichosanthis, Rhizoma Dioscoreae, Fructus Corni, and Radix Salviae Miltiorrizae, on serum sugar of mice or rats with diabetes mellitus induced by alloxan were studied. The result showed that "Xuetangping" (2.5g/kg, ig qd 7d or 14d) lowered serum sugar in diabetic mice but not in normal mice.Xuetangping 1.5g/kg,ig qd 7d or 14d in diabetic in a dose and time dependent manner. While 14d, "Xuetangping" also decreased the value of serum lipid and the content of serum lipid peroxide. This result suggest that antiperoxide activity of this Chinese herbal formulation may be related to its reduction in serum sugar.