[关键词]
[摘要]
用离体动脉条,探讨速效救心丸扩张血管的机理。速效救心丸2mg/ml对去甲基肾上腺素、氯化钾、组织胺、乙酰胆碱、5-羟色胺诱发动脉条收缩均有明显的拮抗作用。不能使去甲肾上腺素量-效曲线平行右移,但降低最大效应,呈非竞争拮抗。它能使氯化钾、氯化钙量-放曲线平行右移,最大效应降低,呈非竞争拮抗。其特点与戊脉胺类似,提示速效救心丸具有钙拮抗作用。
[Key word]
[Abstract]
Suxiaojiuxin pill" at a dose of 2mg/ml obviously inhibited the contraction of isolated rabbit aortic stripes induced by high K+, NA, Ach, His and 5-HT. In comparison with phentolamine, the "pill" did not shift the dose-response curve of NA, but depressed maximum response in a none competititve manner. However, similar to verapamil, it shifted high K+ and Ca++-free high K+ dose response curve to the right at doses of 0.2~0.4mg/ml. PEG as a solvent did not show any effect in the all tests. These results indicated that "Suxiaojiuxin pill" has a Ca++ antagonistic effect in a none competitive manner, mainly by blocking Ca++entry through the potential dependant channel though at high concentrations it may also influenced the NA activated receptor operated channel (ROC ).
[中图分类号]
[基金项目]