当前中药材育种普遍存在“重农艺性状、轻药效物质”的品质退化困境，其重要原因之一在于缺乏对植物生命系统整体性与动态性的深刻理解。以金银花Lonicera japonica为研究对象，突破传统还原论育种的思维桎梏，构建了以系统生命观为引领的金银花系统育种框架。从系统生命观的哲学基础出发，提出了系统生命观的4条核心原则——生命整体性、生长节律性、多维相关性和道地特异性，并建立了该理论框架的数学表达模型与整体分析架构。在此框架指导下，提出了“四位一体”的育种实现路径——系统保护种质资源、系统解析生命机制、系统融合育种技术、系统构建产业生态，并给出了具体的实施路线图。河南金银花育种团队在系统生命观指导下，构建了金银花种质资源保护体系，开展了基于简单重复序列标记的遗传相似性分析（相似系数0.366 7～0.916 7），鉴定了LjTT8等关键功能基因及其“逆境-品质-抗逆”协同调控机制，育成“密银花1号”等系列新品种，实现了系统育种增益，并在产业化推广中取得显著成效，为中药材育种提供兼具理论深度与实践操作性的新范式。

Current breeding of medicinal herbs is generally trapped in quality degradation, characterized by overemphasis on agronomic traits while neglecting pharmacodynamic substances. One major underlying cause is the insufficient in-depth understanding of the integrity and dynamics of plant living systems. Taking Lonicera japonica as the research material, this study breaks the conceptual constraints of conventional reductionist breeding and establishes a systemic breeding framework for honeysuckle guided by the systemic life view (SLV). Starting from the philosophical foundation of SLV, four core tenets are proposed: biological integrity, rhythmic growth, multidimensional correlation, and geo-authentic specificity. Mathematical formulations and an integrative analytical architecture are further constructed for this theoretical framework. Under the guidance of this framework, a four-in-one breeding implementation pathway is put forward, including systemic conservation of germplasm resources, systemic dissection of biological mechanisms, systemic integration of breeding technologies, and systemic construction of industrial ecology, alongside a detailed implementation roadmap. Guided by SLV, the Henan honeysuckle breeding team has established a germplasm conservation system for L. japonica, performed genetic similarity analysis using simple sequence repeat markers with similarity coefficients ranging from 0.366 7 to 0.916 7, identified key functional genes such as LjTT8 and their synergistic regulatory mechanisms linking stress response, quality formation and stress tolerance. New cultivars including ‘Miyinhua 1’ have been developed, achieving genetic gains via systemic breeding and remarkable outcomes in industrial scaling. This work provides a novel paradigm with both theoretical depth and practical operability for medicinal plant breeding.

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国家现代农业产业技术体系建设专项资金资助项目（CARS-21）；中原学者人才项目（264000510011）；河南省外籍科学家工作室资助项目（GZS2024025）