[关键词]
[摘要]
目的 对2006年1月—2026年1月发表的关于中药材道地性的中英文文献进行可视化分析,并梳理相关专利情况,为未来中药材道地性相关领域的深入研究提供参考。方法 通过中国知网(CNKI)和Web of Science(WOS)数据库搜集中药材道地性研究领域的中英文文献,利用CiteSpace 6.4.R1软件对中英文文献的发文量、作者、研究机构、国家以及关键词等进行可视化分析,运用Incopat专利数据库对专利申请趋势、地域分布、申请人、技术主题等进行统计分析。结果 共筛选出1 990篇中文文献,1 050篇英文文献,621项专利族。中国是中药材道地性相关研究发文量最多的国家,科研院所与中医药院校是中药材道地性研究的核心机构,中国中医科学院的中英文发文量均最多。黄璐琦与Yang Jian分别是中英文发文量最多的作者。中药材道地性领域研究的核心团队已初步形成,但团队间合作有待加强。中文文献的研究热点主要为经典名方、本草考证、药理作用、基原、栽培等方面,英文文献更偏向于遗传多样性、人工智能、物候生境、生物合成等交叉学科领域的应用。中国专利的申请量占比为93.08%,近年来申请量保持在20项以上,但存在授权率偏低的问题。山东省申请量位居榜首,中国中医科学院中药研究所与中国科学院东北地理与农业生态研究所申请的专利最多,企业为主要申请人类型。中药材道地性专利主要集中于医疗制剂(A61K)与化合物或药物制剂(A61P)领域,面临着技术同质化较高的问题。结论 中药材道地性的文献研究热度持续增长,而专利布局却遭遇瓶颈。未来研究应立足于中医药经典古籍,积极融合交叉学科技术,诠释中药材道地性的科学内涵,加强对创新理论及技术的保护。
[Key word]
[Abstract]
Objective The Chinese and English literatures on the genuineness of medicinal materials published from January 2006 to January 2026 were visually analyzed, and the related patents were reviewed to provide reference for further research in the field of genuineness of Chinese medicinal materials in the future. Methods Chinese and English literatures in the field of genuineness of medicinal materials were collected through China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases. CiteSpace 6.4.R1 software was used to visually analyze the number of articles, authors, research institutions, countries and keywords of Chinese and English literatures, and Incopat patent database was used to statistically analyze patent application trends, geographical distribution, applicants and technical topics. Results A total of 1 990 Chinese literatures, 1 050 English literatures and 621 patent families were screened out. China was the country with the largest number of publications. Scientific research institutions and traditional Chinese medicine colleges and universities were the core institutions of research on the genuineness of medicinal materials. The Chinese Academy of Chinese Medical Sciences had the largest number of Chinese and English publications. Huang Luqi and Yang Jian were the authors with the largest number of published papers in Chinese and English, respectively. The core team in the field of genuineness of medicinal materials had been initially formed, but the cooperation between the teams needed to be strengthened. The research hotspots of Chinese literature were mainly classical prescriptions, herbal textual research, pharmacological effects, origin, cultivation and so on. English literature was more inclined to the application of interdisciplinary fields such as genetic diversity, artificial intelligence, phenology and habitat and biosynthesis. The proportion of patent applications in China was 93.08%. In recent years, the number of applications had remained above 20, but there was a problem of low grant rate. Shandong Province ranked first in the number of applications. The Institute of Traditional Chinese Medicine of the Chinese Academy of Chinese Medical Sciences and the Northeast Institute of Geography and Agricultural Ecology of the Chinese Academy of Sciences applied for the most patents, and enterprises were the main applicant types. The genuine patents of medicinal materials were mainly concentrated in the fields of A61K (medical preparations) and A61P (compounds or pharmaceutical preparations), facing the problem of high technical homogeneity. Conclusion Research interest in the genuineness of medicinal materials continues to grow, while patent layout has encountered bottlenecks. Future research should be based on the classic ancient books of traditional Chinese medicine, actively integrate interdisciplinary technology, interpret the scientific connotation of the genuineness of medicinal materials, and strengthen the protection of innovative theories and technologies.
[中图分类号]
G350;R282
[基金项目]
重庆市技术创新与应用发展专项面上项目(CSTB2024TIAD-GPX0021);重庆市卫生健康委中医药科研项目(2024ZYQN004);重庆市技术创新与应用发展专项重点项目(CSTB2025TIAD-QQZDQXXCZXBFFX0007)