黄芪Astragali Radix是一种历史悠久的药食两用中药，在《神农本草经》中被列为上品。皂苷作为其最主要的活性成分，具有免疫调节、抗肿瘤、抗病毒及降糖和改善心血管疾病等广泛的药理活性。通过查阅国内外文献，基于中国知网（CNKI）及Web of Science等数据库分析黄芪皂苷的研究现状及研究热点，综述黄芪皂苷的提取分离方法和生物合成途径，进一步探讨黄芪皂苷的生物活性，并阐明其作用机制。通过探讨黄芪皂苷的应用前景，对其今后的药用和商用价值进行展望，为黄芪皂苷产品的深入研究及规模化制备提供参考和思路。

Huangqi (Astragali Radix) is a kind of traditional Chinese medicine with a long history of dual-use in food and medicine. Listed as a top quality in the Shennong’s Classic of Materia Medica (神农本草经). As one of its main active ingredients, saponin has various pharmacological activities such as immunomodulation, antitumor, antivirus, hypoglycemic and cardiovascular improvement. This review mainly analyzes the current research status and hotspots of astragalosides by reviewing domestic and international literature based on Chinese and English literature databases such as China National Knowledge Infrastructure (CNKI) and Web of Science, the extraction and isolation methods and biosynthetic pathways of astragalosides are reviewed, the biological activities of astragalosides are further explored, and the mechanisms of action behind these activities are elucidated. The review also discusses the application prospects of astragalosides, and looks forward to their future medicinal and commercial values, providing references and ideas for the in-depth research and large-scale preparation of astragalosides products.

R284;R285

甘肃省知识产权计划项目（23ZSCQG026）；甘肃省重点研发计划项目（22YF7NA027）；中国科学院“区域发展青年学者”项目（2022-045）