2型糖尿病是一种代谢性疾病，因其高发病率已成为全球卫生领域关注的一大健康问题。肠道微生态与2型糖尿病密切相关，是治疗该病的潜在靶点。黄连Coptis chinensis在治疗糖尿病方面有着良好疗效，具有安全性高、多靶点调控疾病的优势，其中肠道微生态是其发挥抗糖尿病作用的主要靶标之一。因此，收集整理相关研究，系统地阐释黄连活性成分通过肠道微生态发挥抗糖尿病的作用，总结小檗碱、黄连多糖、黄连提取物调节肠道菌群结构及菌群代谢产物、干预肠道靶点、修复肠道屏障及减轻炎症状态的机制，探讨肠道菌群对小檗碱的药物转化作用，为天然药物成分通过调控肠道微生态防治2型糖尿病提供治疗思路。

Type 2 diabetes mellitus (T2DM) is a metabolic disease that has become a major health problem due to its high incidence worldwide. Intestinal microecology is closely related to T2DM and is a potential target for treatment of the disease. Coptis chinensis has a good therapeutic effect on diabetes, with the advantages of high safety and multi-target regulation of the disease. Among them, the intestinal microecology is one of the main targets for its anti-diabetic effect. Therefore, this paper collected and sorted out relevant research, systematically explained the anti-diabetic effect of the active components of C. chinensis through the intestinal microecology, summarized the mechanisms of berberine, C. chinensis polysaccharides, and C. chinensis extracts in regulating the structure of the intestinal flora and the metabolic products of the flora, intervening in intestinal targets, repairing the intestinal barrier, and reducing the inflammatory state, and explored the drug transformation effect of the intestinal flora on berberine, providing therapeutic ideas for the prevention and treatment of T2DM through the regulation of intestinal microecology by natural drug components.

R284

国家自然科学基金面上项目（82474450）