代谢相关脂肪性肝病（metabolic-associated fatty liver disease，MAFLD）是目前最常见的慢性肝病之一，严重威胁人们的健康。研究表明，生物钟在MAFLD的发生和发展中扮演重要角色，尤其是在脂质代谢、胰岛素抵抗、线粒体功能、内质网应激、氧化应激和肠道微生物群等生理过程的调节方面。中医药在MAFLD的治疗中显示出较好的疗效，且具有多靶点、全方位、低毒性等优势。实验研究表明中医药能通过调控生物钟来防治MAFLD。通过对生物钟与MAFLD的关系及中医药通过调控生物钟来防治MAFLD的作用机制进行综述，为MAFLD的中医诊治及新药研发提供参考。

Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases and a serious threat to human health. Studies have shown that the biological clock plays an important role in the occurrence and development of MAFLD, especially in the regulation of several physiological processes, such as lipid metabolism, insulin resistance, mitochondrial function, endoplasmic reticulum stress, oxidative stress, and gut microbiota. TCM has shown better efficacy in the treatment of MAFLD and has the advantages of multi-targeting, omni-directional and low toxicity. Experimental studies have shown that TCM can prevent and treat MAFLD by regulating the biological clock, therefore, this article reviews the relationship between the biological clock and MAFLD, and the mechanism of TCM in preventing and treating MAFLD by regulating the biological clock, with a view to providing references for the diagnosis and treatment of MAFLD and the research and development of new drugs.

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辽宁省教育厅基本科研项目（LJKMZ20221307）