近年来，超微粉碎技术在中药材前处理中的应用日益广泛。该技术通过将中药材粉碎至微米甚至纳米级，显著提高了其中药理活性成分的生物利用率和溶出率，同时也为中药渣的综合利用开辟了新途径。通过系统总结不同中药材在超微粉碎处理中的研究进展，重点讨论了微米级或纳米级下不同种类活性物质溶出行为的变化，深入阐述了超微粉碎技术在中药应用中的优势与挑战。此外，还分析了当前中药渣在不同领域的处理和利用方法，特别关注其在碳材料制备、农业应用和作为饲料添加剂方面的应用。探讨超微粉碎技术在中药领域的应用潜力，并展望其对中药渣资源化利用的贡献，为中药产业的可持续发展提供参考。

In recent years, ultra-fine pulverization technology has been increasingly applied in the pretreatment of traditional Chinese medicine (TCM) materials. This technology significantly enhances the bioavailability and dissolution rate of pharmacologically active ingredients by reducing the particle size of TCM materials to the micron or even nanometer scale, while also opening up new avenues for the comprehensive utilization of Chinese medicine residues. This paper systematically summarizes the research progress of various TCM materials under ultra-fine pulverization treatment, with a focus on the changes in the dissolution behavior of various kinds of active substances at the micro- and nano- scales. Delving into the advantages and challenges of ultra-fine pulverization technology in the application of TCM. Additionally, this paper reviews the current methods of processing and utilizing Chinese medicine residues across different fields, paying special attention to their applications in carbon material preparation, agricultural use, and as feed additives. This review aims to explore the potential applications of ultrafine grinding technology in the field of TCM and its contribution to the resource utilization of Chinese medicine residues, thus providing reference for the sustainable development of TCM industry.

R28

贵州省科技计划项目（黔科平台人才[2021]1350-012号）;国家自然科学基金地区基金项目（32360787）