阿尔茨海默病（Alzheime’s disease，AD）是一种与衰老相关的神经退行性疾病，随着全球老龄化逐渐加剧，AD患病人数直线上升，已经成为严重影响老年群体生活质量的重要疾病。AD病因复杂、病机多样，虽然有缓解病情的药物但效果并不理想。近年来研究发现，栀子可以多靶点、多途径、整体治疗AD，主要通过抑制β-淀粉样蛋白过度聚集、抑制氧化应激、抑制神经炎症、调节大脑胆碱能系统功能、调节自噬功能等作用机制发挥作用。进一步系统总结分析栀子治疗AD相关的研究，为栀子进一步研究与治疗AD提供参考。

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. With the gradual intensification of global aging, the number of AD patients has been increasing steeply, and it has become a significant disease that severely impacts the quality of life of the elderly population. AD is characterized by complex etiology and diverse pathogenesis. Although there are drugs available to relieve the symptoms, their curative effects are far from satisfactory. In recent years, studies have revealed that Zhizi (Gardeniae Fructus) can treat AD in a multi-target, multi-pathway, and holistic manner. It mainly exerts its effects through mechanisms such as inhibiting the excessive aggregation of β-amyloid protein, suppressing oxidative stress, restraining neuroinflammation, regulating the function of the brain cholinergic system, and modulating autophagy function. This study systematically summarizes and analyzes the research related to treatment of AD with Gardeniae Fructus, providing a reference for further research and the application of Gardeniae Fructus in treatment of AD.

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国家自然科学基金资助项目（82205078）;山东省自然科学基金资助项目（ZR2021QH157）