目的 系统性研究莪术的相关研究现状并进行可视化分析，以揭示其研究热点、发展趋势及潜在的创新点。方法 通过中国知网（CNKI）和Web of Science（WOS）的核心合集数据库收集莪术相关的中、英文文献，利用CiteSpace等软件从发文趋势、合作网络（包括发文的国家、机构和核心作者）、主要发文期刊与关键词等方面进行计量学分析与可视化呈现。通过大为Innojoy专利数据库从专利申请趋势、专利地域分布、专利申请人及其竞争力和专利技术主题等方面检索并分析莪术相关全球专利申请情况。结果 共纳入954篇中文文献，231篇英文文献。自2000年1月至2024年10月，莪术的中、英文文献的总发文量呈现阶段性的变化，特别是近3年英文文献年发文量显著增多。合作网络共现分析发现中国为发文主力国家，在莪术的相关研究领域中占据重要地位；中、英文文献发文量最多的研究机构均为南京中医药大学，拥有较高的影响力与较广的合作关系；中、英文文献发文量最多的作者分别是陆兔林和Wang Yitao（王一涛）。发文量最多的中英文期刊分别是《时珍国医国药》与Journal of Ethnopharmacology。关键词共现与聚类分析显示，莪术挥发油等活性成分的化学分析及其药理作用机制为主要研究热点，特别是莪术的抗肿瘤作用研究。目前莪术专利申请正处于较稳定发展状态；中国等亚洲国家申请专利较多，且现有专利保护内容主要集中在莪术的复方或组合物。结论 莪术因其临床抗肿瘤优势，受到国内外学者的广泛关注，且探索其抗肿瘤作用将继续成为莪术未来研究的一个核心方向。同时围绕其基原品种、化学成分以及药理作用，如抗肝纤维化、抗血管生成等开展了大量研究，已成为当前研究热点。但莪术文献研究热点缺少多样性，各发文机构以及核心作者间合作亟待加强等问题也显现出来。已有莪术专利也面临着失效数量多、转化度不高、竞争力不强等问题。今后，莪术抗肿瘤等作用的多靶点机制研究、莪术有效成分新型药物递送系统以及莪术复方制剂的研发等方面值得进一步关注。

Objective To systematically study the current status of relevant researches on Ezhu (Curcumae Rhizoma) and conduct visual analyses in order to reveal its research hotspots, development trends and potential innovations. Methods The Chinese and English literature related to Ezhu was collected through China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) core collection databases. Using CiteSpace and other software, the econometric analyses and visualisations in terms of the trends of publications, the cooperation network (including the countries, institutions and core authors of the publications), the major journals and keywords were carried out. Based on Dawei Innojoy patent database, the global patent applications related to Ezhu were searched and analyzed from the aspects of the trend of patent applications, the geographical distribution of patents, the patent applicants and their competitiveness, and the technical subject of patents. Results A total of 954 Chinese literature and 231 English literature were included. From January 2000 to October 2024, the total number of Chinese and English publications on Ezhu showed a stage-by-stage change, especially in the last three years, the annual number of English publications increased significantly. The co-occurrence analysis of the cooperation network found that China was the leading country in issuing literature, which occupied an important position in the research field related to Ezhu. The research institutions with the most publications in Chinese and English were both Nanjing University of Chinese Medicine, which had a high influence and a wide range of partnerships; The authors with the most publications in Chinese and English were Tulin Lu and Yitao Wang, respectively. The journals with the largest volume of publications of Chinese and English literature were Lishizhen Medicine and Materia Medica Research and Journal of Ethnopharmacology, respectively. Keyword co-occurrence and cluster analysis showed that the chemical analysis of active ingredients such as volatile oil of Ezhu and its pharmacological mechanism of effects were the main research hotspots, especially the research on the anti-tumour effect. At present, the number of patent applications for Ezhu was in a stable development, most patents were applied in Asian countries such as China, and the protection of existing patents mainly focused on the combinations or compositions of Ezhu. Conclusion Ezhu had received extensive attention from scholars both at home and abroad due to its clinical anti-tumour advantages, which will remain a core direction for future research on Ezhu. Meanwhile, a considerable amount of research had been carried out around its original species, chemical composition and pharmacological effects such as anti-hepatic fibrosis and anti-angiogenesis, which already became the current research hotspot. However, the lack of diversity of research hotspots in the literature of Ezhu, as well as the urgent need to strengthen the co-operation between the issuing institutions and the core authors, had also been revealed. The existing patents of Ezhu also faced problems such as high number of invalidations, low degree of transformation and low competitiveness. In the future, it is worthwhile to pay further attention to the study of the multi-target mechanism of Ezhu’s anti-tumour and other effects, as well as the research and development of new drug delivery system of Ezhu’s active ingredients and the Ezhu's compound preparations.

G350;R282.71;R228

国家自然科学基金面上项目（82274099）;四川省科技厅面上项目（24NSFSC1101）;四川省自然科学基金项目（24NSFSC2109）;‌四川省自然科学基金项目（24NSFSC2121）;四川省中医药管理局项目（2023MS499）