[关键词]
[摘要]
目的 研究柳叶菜风毛菊Saussurea epilobioides 的化学成分。方法 利用硅胶、半制备高效液相等色谱技术进行分离纯化,通过核磁共振波谱、质谱等对分得的化合物进行结构鉴定。结果 从柳叶菜风毛菊70%乙醇提取物的醋酸乙酯萃取部位中分离得到31个化合物,分别鉴定为 (4aR,6S,8aS)-6-羟基-6-(3-羟基丙-1-烯-2-基)-4,8a-二甲基-4a,5,6,7,8,8a-六氢萘-2(1H)-酮(1)、3-(2'-羟基-1'-氧代丁酸)-吲哚(2)、吐叶醇(3)、芹菜素(4)、东莨菪内酯(5)、2,3-二氢-4(1H)-喹啉酮(6)、2-(3'',4''-二甲氧基苄基)-3-(3'-甲氧基-4'-羟基苄基)-γ-丁内酯(7)、3,5-二甲氧基-4,9-二羟基-4',7-环氧-3',8-氧杂新木脂素-7'-烯-9'-酸(8)、3-羟基-3-(2-羟乙基)吲哚啉-2-酮(9)、二氢脱氢二松柏醇(10)、黑麦草内酯(11)、去氢吐叶醇(12)、1-(4-羟基-3-甲氧基苯基)-2-[4-(3-羟丙基)-2-甲氧基苯氧基]-丙烷-1,3-二醇(13)、八角莲醇(14)、异地芰普内酯(15)、1-(3-甲氧基-4-羟基苯基)-2-(3-甲氧基-1-羟丙基苯氧基)-3-羟基丙-1-酮(16)、1-(4'-羟基-3'-甲氧基苯基)-2-[4"-(3-羟丙基)-2",6"-二甲氧基苯氧基]丙烷-1,3-二醇(17)、vladinol D(18)、异落叶松脂素(19)、lawsonicin(20)、开环异落叶松脂素(21)、burselignan(22)、vitrifol A(23)、lyratol F(24)、松脂素(25)、肉桂酸(26)、罗汉松脂素(27)、(+)-表松脂酚(28)、2-[4-(3-羟丙基)-2-甲氧基苯氧基]-1,3-丙二醇(29)、3-羟基-1-(4-羟基-3,5-二甲氧基苯基)-1-丙酮(30)、丁香树脂酚(31)。结论 其中化合物1和2为新化合物,分别命名为柳叶醇和柳叶吲哚;化合物6~9、14、16~20、22~24、26、29均是首次从风毛菊属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Saussurea epilobioides. Methods The compounds were separated and purified by various isolation method such as silica gel, semi-preparative high performance liquid chromatography, and the structure of the compounds were identified by nuclear magnetic resonance spectrometry and mass spectrometry.Results A total of 31 compounds were isolated from the ethyl acetate extraction site of 70% ethanol extract of S. epilobioides and identified as (4aR,6S,8aS)-6-hydroxy-6-(3-hydroxyprop-1-en-2-yl)-4,8a-dimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-2(1H)-one (1), 3-(2'-hydroxy-1'-oxobutanoic acid)-indole (2), vomifoliol (3), apigenin (4), scopoletin (5), 2,3-dihydro-4(1H)-quinolone (6), 2-(3'',4''-dimethoxybenzyl)-3-(3'-methoxy-4'-hydroxybenzyl)-γ-butyrolactone (7), 3,5-dimethoxy-4,9-dihydroxy-4',7-epoxy-3',8-oxyneolign- 7'-en-9'-oic acid (8), 3-hydroxy-3-(2-hydroxyethyl)indolin-2-one (9), dihydrodehydrodiconiferyl alcohol (10), loliolide (11), dehydrovomifoliol (12), 1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol (13), dysosmarol (14), isololiolide (15), 1-(3-methoxy-4-hydroxyphenyl)-2-(3-methoxy-1-hydroxypropylphenoxy)-3-hydroxy-propan-1-one (16),1-(4'-hydroxy-3'-methoxyphenyl)-2-[4"-(3-hydroxypropyl)-2",6"-dimethoxyphenoxy]propane-1,3-diol (17), vladinol D (18), (+)-isolariciresinol (19), lawsonicin (20), secoisolariciresinol (21), burselignan (22), vitrifol A (23), lyratol F (24), (+)-pinoresinol (25), cinnamic acid (26), matairesinol (27), (+)-epipinoresinol (28), 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy-propane]-1,3-propanediol (29), 3-hydroxy-1- (4-hydroxy-3,5-dimethoxyphenyl)-1-propanone (30), and syringaresinol (31). Conclusion Among them, compounds 1 and 2 are new compounds, named epilobioides alcohol and epilobioides indole, and compounds 6—9, 14, 16—20, 22—24, 26 and 29 were isolated from the genus Saussurea for the first time.
[中图分类号]
R284.1
[基金项目]
国家重点研发计划资助项目(2019YFC1712302);国家重点研发计划资助项目(2019YFC1712304)