目的 研究柳叶菜风毛菊Saussurea epilobioides 的化学成分。方法 利用硅胶、半制备高效液相等色谱技术进行分离纯化，通过核磁共振波谱、质谱等对分得的化合物进行结构鉴定。结果 从柳叶菜风毛菊70%乙醇提取物的醋酸乙酯萃取部位中分离得到31个化合物，分别鉴定为 (4aR,6S,8aS)-6-羟基-6-(3-羟基丙-1-烯-2-基)-4,8a-二甲基-4a,5,6,7,8,8a-六氢萘-2(1H)-酮（1）、3-(2'-羟基-1'-氧代丁酸)-吲哚（2）、吐叶醇（3）、芹菜素（4）、东莨菪内酯（5）、2,3-二氢-4(1H)-喹啉酮（6）、2-(3'',4''-二甲氧基苄基)-3-(3'-甲氧基-4'-羟基苄基)-γ-丁内酯（7）、3,5-二甲氧基-4,9-二羟基-4',7-环氧-3',8-氧杂新木脂素-7'-烯-9'-酸（8）、3-羟基-3-(2-羟乙基)吲哚啉-2-酮（9）、二氢脱氢二松柏醇（10）、黑麦草内酯（11）、去氢吐叶醇（12）、1-(4-羟基-3-甲氧基苯基)-2-[4-(3-羟丙基)-2-甲氧基苯氧基]-丙烷-1,3-二醇（13）、八角莲醇（14）、异地芰普内酯（15）、1-(3-甲氧基-4-羟基苯基)-2-(3-甲氧基-1-羟丙基苯氧基)-3-羟基丙-1-酮（16）、1-(4'-羟基-3'-甲氧基苯基)-2-[4"-(3-羟丙基)-2",6"-二甲氧基苯氧基]丙烷-1,3-二醇（17）、vladinol D（18）、异落叶松脂素（19）、lawsonicin（20）、开环异落叶松脂素（21）、burselignan（22）、vitrifol A（23）、lyratol F（24）、松脂素（25）、肉桂酸（26）、罗汉松脂素（27）、(＋)-表松脂酚（28）、2-[4-(3-羟丙基)-2-甲氧基苯氧基]-1,3-丙二醇（29）、3-羟基-1-(4-羟基-3,5-二甲氧基苯基)-1-丙酮（30）、丁香树脂酚（31）。结论 其中化合物1和2为新化合物，分别命名为柳叶醇和柳叶吲哚；化合物6～9、14、16～20、22～24、26、29均是首次从风毛菊属植物中分离得到。

Objective To study the chemical constituents from Saussurea epilobioides. Methods The compounds were separated and purified by various isolation method such as silica gel, semi-preparative high performance liquid chromatography, and the structure of the compounds were identified by nuclear magnetic resonance spectrometry and mass spectrometry.Results A total of 31 compounds were isolated from the ethyl acetate extraction site of 70% ethanol extract of S. epilobioides and identified as (4aR,6S,8aS)-6-hydroxy-6-(3-hydroxyprop-1-en-2-yl)-4,8a-dimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-2(1H)-one (1), 3-(2'-hydroxy-1'-oxobutanoic acid)-indole (2), vomifoliol (3), apigenin (4), scopoletin (5), 2,3-dihydro-4(1H)-quinolone (6), 2-(3'',4''-dimethoxybenzyl)-3-(3'-methoxy-4'-hydroxybenzyl)-γ-butyrolactone (7), 3,5-dimethoxy-4,9-dihydroxy-4',7-epoxy-3',8-oxyneolign- 7'-en-9'-oic acid (8), 3-hydroxy-3-(2-hydroxyethyl)indolin-2-one (9), dihydrodehydrodiconiferyl alcohol (10), loliolide (11), dehydrovomifoliol (12), 1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol (13), dysosmarol (14), isololiolide (15), 1-(3-methoxy-4-hydroxyphenyl)-2-(3-methoxy-1-hydroxypropylphenoxy)-3-hydroxy-propan-1-one (16),1-(4'-hydroxy-3'-methoxyphenyl)-2-[4"-(3-hydroxypropyl)-2",6"-dimethoxyphenoxy]propane-1,3-diol (17), vladinol D (18), (+)-isolariciresinol (19), lawsonicin (20), secoisolariciresinol (21), burselignan (22), vitrifol A (23), lyratol F (24), (+)-pinoresinol (25), cinnamic acid (26), matairesinol (27), (+)-epipinoresinol (28), 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy-propane]-1,3-propanediol (29), 3-hydroxy-1- (4-hydroxy-3,5-dimethoxyphenyl)-1-propanone (30), and syringaresinol (31). Conclusion Among them, compounds 1 and 2 are new compounds, named epilobioides alcohol and epilobioides indole, and compounds 6—9, 14, 16—20, 22—24, 26 and 29 were isolated from the genus Saussurea for the first time.

R284.1

国家重点研发计划资助项目（2019YFC1712302）;国家重点研发计划资助项目（2019YFC1712304）