缺血性脑卒中（ischemic stroke，IS）是由脑动脉或颈动脉堵塞引起局部脑组织缺血缺氧的急性血管疾病，具有高发病率、高死亡率和高致残率的特点，严重威胁中老年群体的身体健康和生活质量。目前，溶栓和取栓术是治疗IS的常用方法，但仍有部分患者因各种原因无法接受此类血管再通治疗。近年来的研究表明，中药活性成分在IS治疗中展现出良好效果，相关研究也日益受到重视。通过综述IS的病理发展过程及中药活性成分改善IS的具体作用机制，为缺血性脑卒中的临床治疗策略及中药活性成分的开发提供研究思路和参考。

Ischemic stroke (IS) is an acute cerebrovascular disease caused by blockage of cerebral or carotid arteries, leading to localized cerebral ischemia and hypoxia. It is characterized by high incidence, mortality, and disability rates, posing a serious threat to the health and quality of life of middle-aged and elderly populations. Currently, thrombolysis and thrombectomy are common methods for IS. However, a considerable number of patients are unable to undergo such vascular recanalization therapies due to various reasons. Recent research has shown that many active ingredients of traditional Chinese medicine (TCM) exhibit promising therapeutic effects in the prevention and treatment of IS, garnering increasing attention. This review summarizes the pathological progression of IS and the specific mechanisms by which TCM active components alleviate IS, providing new insights and references for clinical therapeutic strategies and development of TCM-based interventions for IS.

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国家中医药多学科交叉创新团队项目（ZYYCXTD-D-202004）