目的 挖掘《中国药典》2020年版一部（简称《中国药典》）肾病相关中药成方制剂的核心药对，并研究其治疗肾病的作用机制。方法 以《中国药典》为数据来源，使用Excel建立数据库。使用R studio软件通过R环境对数据库进行频次分析、关联规则分析、聚类分析和处方相似度分析。使用VOSviewer软件通过文献计量学的方法筛选肾病相关热点靶点。使用Discovery Studio软件将核心药对治疗肾病的主要化学成分和肾病热点靶点进行分子对接，探究其作用机制。结果 数据库中包含中药处方166首，中药347味，药味总频次1 786次。Apriori和Eclat关联规则分析得到核心药对“山药-茯苓”；聚类分析和相关性分析得到核心药对“山茱萸-牡丹皮”；处方相似度分析得到核心处方六味地黄丸。文献计量学研究得到肾病相关热点靶点转化生长因子-β1（transforming growth factor-β1，TGF-β1）和通路TGF-β1/Smad。分子对接研究表明核心药对通过作用于TGF-β1/Smad信号通路发挥治疗肾病的作用。结论 研究挖掘了《中国药典》中治疗肾病的核心药对，并预测了其作用机制，对指导临床用药、发现新药以及中医药现代化提供了研究思路和方法。

ObjectiveTo explore the core drug pairs from traditional Chinese medicine (TCM) prescription related to kidney disease in the first part of the 2020 edition of Chinese Pharmacopoeia (Chinese Pharmacopoeia for short), and study its mechanism of action in the treatment of kidney disease. Method Chinese Pharmacopoeia was used as the data source, and Excel was used to establish the database. Frequency analysis, association rule analysis, cluster analysis and prescription similarity analysis were performed on the database through R environment using R studio software. VOSviewer software was used to screen the hot targets related to kidney disease by bibliometric methods. Discovery Studio software was used to molecular dock between the main chemical components of the core drugs in the treatment of nephropathy and the hotspot targets of nephropathy to explore their mechanisms of action. ResultsThe database contained 166 TCM prescriptions, 347 TCMs, and the total frequency of the flavors was 1 786 times. Apriori and Eclat association rules were analyzed to obtain the core drug pair of Shanyao (Dioscoreae Rhizoma)-Fuling (Poria). Cluster analysis and correlation analysis were used to obtain the core pairs of Shanzhuyu (Corni Fructus)-Mudanpi (Moutan Cortex). Prescription similarity analysis obtained the core prescription Liuwei Dihuang Pills. The bibliometric study obtained the hotspot target transforming growth factor-β1 (TGF-β1) and the pathway TGF-β1/Smad related to renal disease, and the molecular docking study indicated that the core pair could play a therapeutic role in the treatment of kidney disease by acting on the TGF-β1/Smad signaling pathway. Conclusion This study excavated the core drug pairs for the treatment of kidney disease in Chinese Pharmacopoeia, predicted their mechanism of action, and provided research ideas and methods for clinical drug guidance, new drug discovery and modernization of TCM.

R285;G350

国家自然科学基金青年科学基金项目(82104531);国家自然科学基金面上项目(82074121);国家中医药管理局高水平中医药重点学科建设项目-中药化学