[关键词]
[摘要]
毛蕊花糖苷是一种在双子叶植物中广泛分布的水溶性苯乙醇糖苷类化合物。大量研究表明其具有抗肿瘤、抗炎、抗皮肤损伤、抗神经损伤等药理活性,尤其在抑制肿瘤细胞生长、缓解炎症反应、改善神经功能障碍等方面作用突出,展现出良好的潜在应用价值,但因其多羟基易氧化且生物利用度差的特点,给其制剂研发带来了更大的挑战。结合国内外近年相关文献,综述了毛蕊花糖苷在药理作用以及制剂研发方面的研究进展,为相关领域的制剂开发与临床应用提供参考依据。
[Key word]
[Abstract]
Verbascoside is a water-soluble phenylethanol glycoside widely distributed in dicotyledonous plants. A large number of studies have proven that it has various pharmacological activities such as antitumor, anti-inflammatory, anti-skin damage, and anti-nerve damage. It is especially effective in inhibiting the growth of tumor cells, alleviating inflammatory reactions, and improving neurological dysfunction, showing good potential applications. However, its polyhydroxyl groups are easily oxidized and have poor bioavailability, which brings greater challenges to the development of its preparations. This article combines relevant literature at home and abroad in recent years to review the research progress of verbascoside in pharmacological effects and preparation development, which will provide a reference for preparation development and clinical application in related fields.
[中图分类号]
R285
[基金项目]
四川省科学技术厅重点研发项目(2023YFS0347);四川省中医药管理局项目(2024MS538)