[关键词]
[摘要]
结直肠癌（colorectal cancer，CRC）作为国内外常见的恶性肿瘤，严重影响人们的生命健康，传统的治疗手段对生存期的改善有限，因此，寻求新的治疗方式成为目前研究的热点之一。其中，植物化合物小檗碱对于CRC的治疗作用逐渐受到关注，它具有抑制肿瘤细胞的增殖迁移、促进肿瘤细胞的自噬凋亡、改善肠道菌群及代谢等作用。通过对小檗碱在结直肠癌治疗中的作用机制进行综述，为进一步开发小檗碱的抗肿瘤作用以及形成中医药治疗CRC的治疗策略提供一定的理论参考。
[Key word]
[Abstract]
Colorectal cancer (CRC), as a common malignant tumor at home and abroad, seriously affects people’s life and health. Traditional treatments have limited effects on survival. Therefore, seeking new treatment methods has become one of the hot spots in the current research. Among them, the plant compound berberine has gradually received attention for its therapeutic effect on CRC, which can inhibit the proliferation and migration of tumor cells, promote the autophagy apoptosis of tumor cells, improve intestinal flora and metabolism. This article reviews the mechanism of action of berberine in the treatment of CRC, so as to provide some theoretical reference for the further development of the anti-tumor effect of berberine and the formation of the therapeutic strategy of traditional Chinese medicine in the treatment of CRC.
[中图分类号]
[基金项目]
国家自然科学基金资助项目（82002479）；江苏省自然科学基金资助项目（BK20200179）；常州市科技局基础研究项目（CJ20200116）；常州市卫计委青年人才开发计划（CZQM2020006）；常州市青年科技人才支持项目（2021）引进国外人才专项计划（CQ20214031）；2022年常州市“十四五”卫生健康高层次人才培养项目（KY20221354，KY20221355）；仙连解毒优化方预防结肠癌术后复发的临床研究（KY20231612）；β-葡聚糖调控肠腺瘤样息肉瘤内微生物群的作用（ZD202302）
