脑缺血及其再灌注损伤是全球人口死亡和致残的主要原因之一，从天然植物或药物中提取单体开发神经保护剂已成为治疗脑缺血损伤的关键方法。白藜芦醇作为一种天然多酚类化合物，广泛存在于植物与食物中。大量研究表明白藜芦醇可通过保护血脑屏障、抑制炎症反应、抗氧化应激、抑制细胞凋亡、调节自噬等多种途径改善脑缺血损伤。在治疗及预防脑缺血损伤方面，白藜芦醇的有效性已被证实，但其具体的作用机制及分子靶点尚未完全阐明。因此，通过分析近10年国内外相关文献，对白藜芦醇治疗脑缺血损伤的作用靶点及机制研究、药动学、药物递送系统及安全性评价等进行综述，为白藜芦醇的开发和推广应用提供理论依据。

Cerebral ischemia and reperfusion injury is the leading cause of disability and death worldwide. The development of neuroprotective agents from natural plants or drugs has become a key approach to the treatment of cerebral ischemia injury. Resveratrol, as a natural polyphenolic compound, is widely found in plants and foods. Many studies have shown that resveratrol can improve cerebral ischemia injury by protecting the blood-brain barrier, inhibiting inflammatory response, anti-oxidative stress, inhibiting apoptosis, regulating autophagy and other ways. The great potential of resveratrol in the treatment and prevention of cerebral ischemic injury has been confirmed, but its specific mechanism of action and molecular targets have not been fully elucidated. Therefore, based on the analysis of relevant literature at home and abroad in the past 10 years, the target and mechanism studies, pharmacokinetics, drug delivery system and safety evaluation of resveratrol in the treatment of cerebral ischemic injury were reviewed, in order to provide theoretical basis for the further development and application of resveratrol.

山东省自然科学基金资助项目（ZR2020KH003）；济南市高校院所创新团队项目（2020GXRC012）；山东中医药大学青年创新团队项目（2020-54-19）