[关键词]
[摘要]
马钱子Strychni Semen为我国传统有毒中药,药用历史悠久、疗效显著,其化学成分复杂多样,主要包括生物碱、酚酸、萜类、甾体及苷类等,对骨骼、神经、心血管系统均有显著的药理作用,在镇痛、抗肿瘤方面药效显著。随着现代科学技术的发展与应用,马钱子新的化学成分和药理活性不断被发现,具有广阔的开发应用前景。以质量标志物(quality marker,Q-Marker)的理论为指导,总结马钱子化学成分和药理作用的研究进展,从亲缘关系、传统药性、药效、毒性、炮制、成分可测性和入血成分等方面对其Q-Marker进行预测分析,为马钱子更加科学合理的质量评价体系建立及其进一步开发利用提供参考。
[Key word]
[Abstract]
Maqianzi (Strychni Semen) is a poisonous traditional Chinese medicine with a long history and remarkable curative effect. Its chemical components are complex, including alkaloids, phenolic acids, terpenoids, steroids and glycosides, etc., which have shown significant pharmacological effects on bone, nervous and cardiovascular system, especially unique analgesia and anti-tumor effects. With the development and application of modern scientific research technology, new chemical constituents and pharmacological activities of Strychni Semen have been discovered constantly, which has a broad prospect of development and utilization. Based on the theory of quality marker (Q-Marker), this paper summarizes the chemical constituents and pharmacological activities of Strychni Semen, predicts and analyzes its Q-Marker from the aspects such as genetic relationship, traditional medicine property, efficacy, toxicity, processing, measurable components and blood components of Strychni Semen, with view to providing the references for establishing a more scientific and reasonable quality evaluation system of Semen Strychni and its further development and utilization.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(81873083)