海洋中药应用历史悠久，是海洋生物资源和中医药研究中的重要组成部分。肿瘤一直以来都是人类面临的重大难题，化疗药物不良反应大、易耐药等问题日渐突出，现代研究已证实多种海洋中药具有显著的抗肿瘤作用，开发潜力较大，因此从该领域筛选合适的抗肿瘤药物意义重大。通过文献挖掘《海洋中药学》中记载的250种经典海洋中药，发现抗肿瘤作用已得到验证的有47种，清热解毒类、补虚类、化痰止咳平喘类、祛风湿类海洋中药占比较大，其药效物质主要为多肽、多糖类成分。综述具有抗肿瘤作用的海洋中药，为海洋中药更深层次的抗肿瘤研究提供一定的借鉴意义和思路方法。

Marine traditional Chinese medicine (TCM) has a long history of application, and is an important part of marine biological resources and TCM research. Tumor has always been a major challenge for mankind. The problems of large adverse reactions and easy drug resistance to chemotherapeutic drugs are becoming increasingly prominent. Modern research has confirmed that a variety of marine TCMs have significant antitumor effects and great development potential. Therefore, it is significant to screen appropriate antitumor drugs from this field. In this paper, through the literature mining of 250 classical marine TCM recorded in "Marine Traditional Chinese Medicine", it is found that 47 kinds of antitumor effects have been verified, the proportion of marine TCMs such as heat clearing and toxin removing classes, tonify deficiency classes, resolving phlegm and relieving cough and asthma classes, and dispel rheumatism classes are relatively large, and their pharmacodynamic substances are mainly peptides and polysaccharides. The review of marine TCM with the anti-tumor effects will provide some reference significance and ideas and methods for the deeper anti-tumor research of marine TCM.

中国-东盟传统药物研究国际合作联合实验室建设(二期)新中心建设项目(CICAR2017-Z1);广西科技基地和人才专项(桂科AD191101553);广西创新驱动重大专项(桂科AA181180492);广西创新驱动重大专项(桂科AA192540334)