目的 探讨血尿安胶囊联合左氧氟沙星治疗围绝经期妇女泌尿系感染（肝郁脾虚、下焦湿热型）的临床疗效及安全性。方法 120例围绝经期妇女泌尿系感染（肝郁脾虚、下焦湿热型）患者按照随机数字表法分为对照组和治疗组，每组60例。对照组患者给予盐酸左氧氟沙星片（0.6 g/d）治疗；治疗组患者在对照组的基础上给予血尿安胶囊（4.2 g/d）联合治疗。两组均治疗2周。观察两组的临床疗效，比较两组患者治疗前后尿白细胞镜检指标、尿细菌培养转阴率、复发率、血常规、腹部B超、肝肾功能指标及药物不良反应情况。结果 治疗后，对照组和治疗组的总有效率分别为68.33%、95.00%，两组比较差异具有统计学意义（P＜0.05）；治疗组尿频、尿急、尿痛症状改善时间均明显短于对照组（P＜0.05），尿细菌培养转阴率明显优于对照组（P＜0.05）。治疗后，与治疗前比较两组白细胞计数和尿细菌培养菌落数均显著降低（P＜0.05），且治疗组白细胞计数和尿细菌培养菌落数明显低于对照组（P＜0.05）。随访6个月治疗组复发率（3.33%）明显低于对照组（31.67%），两组比较差异具有统计学意义（P＜0.05）。两组均未出现明显不良反应。结论 血尿安胶囊联合左氧氟沙星在治疗围绝经期妇女泌尿系感染（肝郁脾虚、下焦湿热型）的过程中，可有效改善临床症状，清除尿病原菌，降低复发率，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Xueniaoan Capsule (血尿安胶囊) combined with levofloxacin in the treatment of urinary tract infection in perimenopausal women with liver depression and spleen deficiency and damp-heat in lower jiao syndrome. Methods A total of 120 patients with urinary tract infection in perimenopausal women with liver depression and spleen deficiency and damp-heat in lower jiao syndrome were randomly divided into control group (n = 60) and treatment group (n = 60). The control group was treated with levofloxacin hydrochloride tablets (0.6 g/d, po) and the treatment group was treated with Xueniaoan Capsule (4.2 g/d, po) combined with levofloxacin hydrochloride tablets (0.6 g/d, po). Both groups were continuously treated for two weeks. The clinical efficacy of the two groups was observed, and the indicators of urine leucocyte microscopic examination, urine bacterial culture negative rate, recurrence rate, blood routine examination, abdominal B-ultrasound, liver and kidney function indexes and adverse drug reactions of the two groups were compared before and after treatment. Results After treatment, the total effective rate in the control and treatment groups were 68.33% and 95.00%, respectively, and there were statistical differences between two groups (P < 0.05); The improvement time of clinical symptoms and negative rate of urine bacteria culture in the treatment group were significantly better than the control group (P < 0.05); After treatment, white blood cell count and urine bacterial culture colony number in both groups were significantly decreased compared with before treatment (P < 0.05), and white blood cell count and urine bacterial culture colony number in the treatment group were significantly lower than those in the control group (P < 0.05); The recurrence rate of the treatment group (3.33%) was significantly lower than that of the control group (31.67%) after six months follow-up, and the difference between the two groups was statistically significant (P < 0.05); Adverse reactions were not evident in either group. Conclusion During the treatment of Xueniaoan Capsule combined with levofloxacin with urinary tract infection in perimenopausal women with liver depression and spleen deficiency and damp-heat in lower jiao sydrome, can effectively relieve the clinical symptoms, improve the pathogen clearance and reduce the rate of recurrence, which has a certain clinical application value.

R285.4