目的 研究菊科蜂斗菜属植物毛裂蜂斗菜Petasites tricholobus全草中倍半萜类化学成分。方法 采用正相硅胶、反相硅胶、葡聚糖凝胶、微孔树脂等多种柱色谱填料进行分离纯化，并运用MS、NMR、UV、IR等现代波谱分析技术对化合物结构进行鉴定。结果 从毛裂蜂斗菜50%乙醇提取物中分离得到5个倍半萜类化合物，分别鉴定为1α-(cis- methylthioacryloyloxy)-8α-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene（1）、bakkenolide IIIb（2）、monoketone（3）、japonipene C（4）和petatewalide A（5）。结论 化合物1为新化合物，命名为毛裂蜂斗菜素；化合物2～5均为首次从毛裂蜂斗菜中分离得到。

Objective To study sesquiterpenoids from the herb of Petasites tricholobus of Compositae family. Methods The compounds were isolated and purified by silica gel, ODS, Sephadex LH-20, MCI, etc. Their structures were identified by extensive analysis of MS, NMR, UV, IR data and so on. Results Five sesquiterpenoids were isolated from the 50% ethanol extract of P. tricholobus. and identified as 1α-(cis-methylthioacryloyloxy)-8α-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene (1), bakkenolide IIIb (2), monoketone (3), japonipene C (4) and petatewalide A (5). Conclusion Compound 1 is a new sesquiterpenoid named petatricholide, and compounds 2—5 were isolated from P. tricholobus for the first time.

R284.1

国家自然科学基金资助项目（81603270）