目的 采用Python语言数据挖掘中药治疗卒中后认知障碍(post stroke cognitive impairment,PSCI)的用药规律,为PSCI的临床治疗提供依据。方法 计算机检索中国知网、万方、维普、中国生物医学4个中文数据库,PubMed、EmBase、Cochrane Library 3个英文数据库及Clinical Trials.gov、中国临床试验注册中心(ChiCTR)2个临床试验注册系统,纳入中药治疗PSCI的随机对照研究。采用Epidata建立数据库,运用Python语言对中药使用频次、相关性、关联规则和聚类进行数据分析。结果 共纳入155首治疗PSCI的经验方药,中药共214味,频次共1685次,其中使用频次>60次的药物依次为石菖蒲、川芎、远志、丹参,使用频次>10次的药物以补虚类、活血化瘀类及化痰类中药为主,相关系数较高的前10味药物组合多为补虚药和活血化瘀药,关联规则和聚类分析形成以石菖蒲、远志和川芎为主的核心药物组方。结论 中药治疗PSCI的核心药物组方为石菖蒲、远志和川芎,在此基础上可加入针对PSCI肾精亏虚为本、痰瘀互结为标的相应中药,以达先后天同调、扶正祛邪、标本同治之则。在未来的研究中,需关注PSCI的核心药物组方,开展药学、药效学及临床试验等研究,为中药治疗PSCI提供新策略。

Objective Python language data was used to mine the medication rules of traditional Chinese medicine (TCM) in the treatment of post stroke cognitive impairment (PSCI), providing the basis for the clinical treatment for PSCI. Methods Four Chinese databases including CNKI, Wanfang, VIP and CBM, three English databases including PubMed, EmBase, and Cochrane Library, and two clinical trial registration systems including Clinical Trials.gov and China Clinical Trial Registration Center (ChiCTR) were searched by computer. A randomized controlled study of TCM in the treatment of PSCI was included. Epidata was used to build a database, and Python language was used to analyze the frequency, correlation, association rules and clustering of TCM. Results A total of 155 prescriptions of TCM for the treatment of PSCI were included. There were a total of 214 TCM with a frequency of 1685 times. Shichangpu (Acori Tatarinowii Rhizoma), Yuanzhi (Polygalae Radix), Chuanxiong (Chuanxiong Rhizoma), Danshen (Salviae Miltiorrhizae Radix et Rhizoma) were used more than 60 times. The drugs used more than 10 times were mainly tonifying deficiency, activating blood circulation to dissipate blood stasis, and reducing phlegm. The top 10 drug pairs with higher correlation coefficient were tonifying deficiency and activating blood circulation to dissipate blood stasis. Association rules and cluster analysis were used to form the core medicine prescriptions dominated by Acori Tatarinowii Rhizoma, Polygalae Radix, Chuanxiong Rhizoma.Conclusion Acori Tatarinowii Rhizoma, Polygalae Radix, and Chuanxiong Rhizomaare the core herbs of TCM in the treatment of PSCI. On this basis, it can be added TCM for PSCI's deficiency of the kidney and the spleen and intermin-gled phlegm and blood stasis as the target, to achieve the principle of coordinating the nature of the day, strengthening the body and eliminating the evil, and treating the symptoms and the root causes. In future research, attention should be paid to the core medicine prescriptions of PSCI, and research and clinical trials such as pharmacy and pharmacodynamics should be carried out to provide new strategies for the treatment of PSCI with TCM.

R285.4

中国中医科学院科技创新工程项目（CI2021A01310）；中医药防治脑病传承创新团队项目（CI2021B006）；国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-C-202007）；国家中医药管理局中医药传承与创新“百千万”人才工程（岐黄学者项目-国家中医药领军人才支持计划）（国中医药人教发[2018]12号）